Endocrine Abstracts

Introduction and aim: Polycystic ovary syndrome (PCOS) is associated with an adverse metabolic and cardiovascular risk (CVR) profile, including: diabetes, insulin resistance, dyslipidemia and hypertension. Heart rate recovery (HRR) is a measure of autonomic dysfunction and an abnormal HRR is also associated with increased mortality. To date, no evaluation of autonomic function in young PCOS women has been performed, therefore the aim of the present study was to evaluate the HR...

Mineralocorticoid Receptor (MR) is able to regulate the transcription of a number of genes in the myotube, nevertheless the role of this steroid hormone receptor in skeletal muscle (SM) metabolism needs to be clarified. SM represents a major site for glucose uptake and local metabolic derangements play a pivotal role in the development of insulin resistance (IR). The aim of this study was to investigate the contribution of MR in mediating SM metabolic alterations in a mouse mo...

Background: Many questions concerning Turner Syndrome (TS) remain unresolved, such as the long-term complications and, therefore, the optimal care setting for adults. Most controversials regard tumors. Very few data are available on thyroid carcinoma and no specific screening protocol of monitoring is advised in the current official guidelines. This long-term cohort study was primarily aimed at estimating the incidence and time to comorbid conditions along the life course, inc...

Introduction: With the increasing survival rates from cancer the focus has been shifting towards the adverse sequelae, occurring both acutely, or developing as late effects, deriving from its multimodality treatment.Aim: We investigated the occurrence of thyroid complications in patients with haematological malignancies treated with chemotherapy, radiotherapy involving the neck and/or haematopoietic stem cell transplantation (HSCT), referred to our endoc...

Objective: higher aldosterone (aldo) levels are associated with increased risk of cardiovascular ischemic events and mortality. It has been demonstrated that aldo accelerates the development of aterosclerosis in apolipoprotein E knockout mice (ApoE KO). Ketogenic diet (KD) positively impacts several cardiovascular risk factors, yet its effect on atherosclerosis, is elusive. We hypothesize that, KD protects from development of atherosclerotic plaques in ApeE KO mice, a murine m...

Introduction and Aim: Obesity is associated with an increased risk of hypothyroidism and chronic autoimmune thyroiditis (AIT). However, little is known about the underlying pathogenic mechanisms. Recently it has been evaluated the role played by sex hormones in the onset of AIT and, analysing the data from a large cohort of normal/overweight males, a positive correlation between an increased ratio of estradiol/testosterone levels (E2/T) and AIT was found. Since obese males are...

Background and Aim: American Thyroid Association (ATA) guidelines do not consider age at diagnosis of differentiated thyroid cancer (DTC) as a prognostic factor in the estimation of risk of recurrence and persistent disease. While age at diagnosis has already been assessed in high-risk patients, it remains to be established whether there is a correlation between age at diagnosis and long term outcome in DTC patients.Methods: We retrospectively evaluated ...

Purpose: The hormonal thyroid changes related to obesity, even when in the euthyroid state, may contribute to the unfavorable cardio-metabolic profile of obese patients. In this retrospective study we aim to investigate the biochemical thyroid changes and the association between serum TSH, FT4, FT3 and cardio-metabolic risk factors in euthyroid obese youths.Methods: Four hundred ninety-one Caucasian euthyroid obese children and adolescents aged 9.93±2...

Introduction: It is known that very-low-calorie-ketogenic-diet (VLCKD) has beneficial effects on body weight in overweight diabetic patients. Adopting this diet with artificial meals or natural foods in type 2 diabetes (T2DM) has been largely studied, and conflicting results have been reported regarding its effects on glycemic profiles, dyslipidemia, and liver function. In fact, the high level of fat content in natural foods could have a negative impact on hepatic steatosis, a...

Introduction: Diabetes mellitus (DM) develops early in Turner syndrome (TS) and appears not related to common risk factors. The precise mechanism of its development is still a matter of debate: a defective insulin response seems to be involved, but the role of incretins is still undefined.Objective: To evaluate the implication of incretin release in the early stages of DM development in TS. Materials and Methods: 153 Turner patient...